Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression
Tkalcević VI, Cuzić S, Brajsa K, et al. European Journal of Pharmacology 2007;570:212-221.
What it found
PL 14736, the same peptide under its development code, built granulation tissue about as well as the growth factor PDGF-BB and organised early collagen better, in rats and in diabetic mice. In gut cells it switched on the egr-1 gene faster.
Limitations
The mechanism comes from a gut cell line. The study was run by the company developing the peptide (Pliva).
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