Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption
Johansen PB, Hansen KT, Andersen JV, et al. Xenobiotica 1998;28:1083-1092.
What it found
Ipamorelin was cleared from plasma about 5 times more slowly than GHRP-6 and was mainly excreted in urine. 60-80% of the dose of the newer peptides was recovered intact in bile and urine. Nasal bioavailability of ipamorelin was about 20%.
Limitations
Male rats only. Pharmacokinetics only, no effects measured.
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