Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al. European Journal of Endocrinology 1998;139:552-561.
What it found
Ipamorelin released growth hormone with potency and efficacy similar to GHRP-6, through the GHRP receptor. In pigs it did not change FSH, LH, prolactin or TSH, and unlike GHRP-6 and GHRP-2 it did not raise ACTH or cortisol above the levels seen with GHRH.
Limitations
Rat cells, rats and pigs only; acute single-dose experiments. Selectivity was not tested in humans here.
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