Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. Brain Research 2006;1117:54-60.
What it found
BDNF protein rose up to 1.4-fold and trkB activation 1.6-fold in the hippocampus, with 3-fold and 2-fold rises in the corresponding gene messages. Treated rats made more conditioned avoidance responses.
Limitations
Rats only, single dose. From the Institute of Molecular Genetics, Moscow.
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