Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
Dmitrieva VG, Povarova OV, Skvortsova VI, et al. Cellular and Molecular Neurobiology 2010;30:71-79.
What it found
After permanent blockage of a brain artery, Semax increased transcription of BDNF, NT-3, NGF and their receptors (TrkA, TrkC) in the damaged cortex at different time points. Its Pro-Gly-Pro tail alone had less specific effects.
Limitations
Rats only. Measures gene activity, not stroke size or recovery. From the Institute of Molecular Genetics, Moscow.
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