Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
Jetté L, Léger R, Thibaudeau K, et al. Endocrinology 2005;146:3052-3058.
What it found
Three albumin-binding versions of GRF (1-29) were made. CJC-1295, a tetrasubstituted GRF (1-29) with an added lysine carrying a maleimide group (the albumin-binding version), gave a 4-fold larger growth hormone response over 2 hours than GRF (1-29) and was still present in plasma beyond 72 hours, bound to albumin.
Limitations
Rats and rat cells only. This is the DAC version; it does not describe the short-acting version without DAC.
Research and education only. Not medical advice. Many peptides on this site are not approved by the FDA for human use. Doses shown are the ones used in published studies and are not a recommendation. Talk to a licensed clinician before using any of them. Read the full disclaimer.