Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence
Jain A, Gallacher DM, Issa MA, et al. International Journal of Molecular Sciences 2026;27:8922.
What it found
Separates synthetic epitalon from the older pineal extract epithalamin. Concludes that epitalon is biologically active but clinically unproven: human evidence is limited to small biomarker studies and an older retinitis pigmentosa study, and pharmacokinetic, dosing and long-term safety data are inadequate.
Limitations
Narrative review, not systematic.
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