Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells
Pickart L, Freedman JH, Loker WJ, et al. Nature 1980;288:715-717.
What it found
The plasma tripeptide (glycyl-histidyl-lysine) co-purified with copper, readily formed copper complexes, and increased copper uptake into cultured liver cancer (hepatoma) cells. The authors proposed that it acts as a copper transport factor.
Limitations
Cell culture only. An early foundational study by the scientist who first described GHK.
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