Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects
Tomas FM, Knowles SE, Owens PC, et al. Biochemical Journal 1993;291:781-786.
What it found
IGF-1 and its variants restored growth and nitrogen balance in diabetic rats, with LR3 and des(1-3)IGF-I 2.5-3 times more potent than IGF-1, and raised muscle protein synthesis by up to 50%. Unlike insulin, they did not reduce sugar loss in urine or muscle protein breakdown.
Limitations
Rats with chemically induced diabetes; short study.
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