Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
George JT, Veldhuis JD, Roseweir AK, et al. Journal of Clinical Endocrinology and Metabolism 2011;96:E1228-E1236.
What it found
LH rose quickly and in proportion to dose, peaking at 1 µg/kg (from 4.1 to 12.4 IU/L at 30 minutes); 3 µg/kg gave a smaller response. The high-rate infusion raised LH from 5.4 to 20.8 IU/L and testosterone from 16.6 to 24.0 nmol/L. The lower-rate infusion raised LH pulse frequency from 0.7 to 1.0 pulses per hour.
Limitations
Very small groups (4 to 6 men per experiment). Healthy young men only; hours, not weeks. Compared with vehicle, but the abstract does not describe randomisation or blinding.
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