Kisspeptin resets the hypothalamic GnRH clock in men
Chan YM, Butler JP, Pinnell NE, et al. Journal of Clinical Endocrinology and Metabolism 2011;96:E908-E915.
What it found
Each dose triggered an immediate LH pulse, larger on average than natural pulses (5.0 vs 2.1 mIU/mL), and delayed the next natural pulse by about one normal interval. The authors concluded that kisspeptin resets the GnRH pulse generator.
Limitations
13 healthy men. A physiology study of hormone timing, not of any health outcome.
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