Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay
Chan YM, Lippincott MF, Sales Barroso P, et al. Journal of Clinical Endocrinology and Metabolism 2020;105:e2717-e2725.
What it found
All 8 children whose LH rose by 0.8 mIU/mL or more after kisspeptin later went through puberty; all 8 with a rise of 0.4 mIU/mL or less reached 18 without signs of puberty. The kisspeptin test predicted outcomes better than GnRH testing, inhibin B or genetic testing.
Limitations
16 children (3 girls, 13 boys) at one centre. The abstract says "kisspeptin" without naming the form. Diagnostic use only.
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