Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman L, Chwalek K, Sinclair DA. Cell Metabolism 2018;27:529-547.
What it found
Explains NAD+ as both an energy-metabolism coenzyme and a signalling molecule, describes its decline with age in animals, and reviews animal evidence that restoring NAD+ (mostly with precursors) can improve health and lifespan.
Limitations
Narrative review written before most human trials were published; the evidence it reviews is mainly from animals.
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