Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD(+) Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Elhassan YS, Kluckova K, Fletcher RS, et al. Cell Reports 2019;28:1717-1728.e6.
What it found
Precursor study (NR). In 12 older men, NR raised NAD-related molecules in muscle and lowered some inflammatory signals in blood, but did not change how well muscle mitochondria produced energy.
Limitations
Very small, men only, three weeks.
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