Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
Martens CR, Denman BA, Mazzo MR, et al. Nature Communications 2018;9:1286.
What it found
Precursor study (NR, not NAD+). NR was well tolerated and raised NAD+ metabolism in blood cells. Blood pressure and arterial stiffness showed possible improvements that the authors said need testing in larger trials.
Limitations
Small crossover, short duration. Physiological effects were exploratory.
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