Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra
Rosen RC, Diamond LE, Earle DC, et al. International Journal of Impotence Research 2004;16:135-142.
What it found
In healthy men, doses above 1.0 mg produced measurable erections. In men with an inadequate response to sildenafil (Viagra), both 4 mg and 6 mg produced erections more often than placebo during visual sexual stimulation. Reported as well tolerated.
Limitations
Small, short-term early-phase studies. Erections measured in the lab, not during sexual activity at home. Development in men did not lead to approval.
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