Randomised controlled trial

Tirzepatide Once Weekly for the Treatment of Obesity

Jastreboff AM, Aronne LJ, Ahmad NN, et al. New England Journal of Medicine 2022;387:205-216.

What it found

Mean body weight change of -15.0% (5 mg), -19.5% (10 mg) and -20.9% (15 mg) vs -3.1% with placebo.

Limitations

Adults without diabetes. Participants also received lifestyle counselling.

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