Dosage chart, U-100 syringe units and supplies for a 20 mg vial of Tirzepatide mixed with 2 mL. For the full research summary, see the Tirzepatide page.
Amounts as reported for this peptide, with the syringe measure for this vial. Reported use is not evidence that a schedule works or is safe, and none of this is medical advice.
| Period | Amount each time | U-100 units | Volume |
|---|---|---|---|
| Weeks 1-4 | 2.5 mg | 25 | 0.25 mL |
| Weeks 5-8 | 5 mg | 50 | 0.5 mL |
| Weeks 9-12 | 7.5 mg | 75 | 0.75 mL |
| Weeks 13-16 | 10 mg | 100 | 1 mL |
| Weeks 17-20 | 12.5 mg | 2 injections of 62.5 units | 1.25 mL |
| Week 21 on | 15 mg | 2 injections of 75 units | 1.5 mL |
Minimum supplies for each length of the schedule above, with 20 mg vials and 2 mL of water per vial. One new syringe per injection (two if over 1 mL), two alcohol swabs per injection, 10 mL water bottles.
| Item | 12 weeks | 24 weeks |
|---|---|---|
| Injections | 12 | 24 |
| Total peptide | 60 mg | 210 mg |
| Tirzepatide vials (20 mg) | 3 | 11 |
| Bacteriostatic water | 6 mL | 22 mL |
| Water bottles (10 mL) | 1 | 3 |
| U-100 insulin syringes | 12 | 32 |
| Alcohol swabs (boxes of 100) | 24 (1) | 64 (1) |
For laboratory research use only.
Codex Research LabShips from Panama City · US domestic shipping
Try other volumes of water: the concentration and the units per amount change with it.
Arithmetic only. It assumes the vial holds exactly what the label says.
| Liquid added | Concentration | Per unit |
|---|---|---|
| 1 mL | 20,000 mcg/mL | 200 mcg |
| 2 mL | 10,000 mcg/mL | 100 mcg |
| 3 mL | 6,667 mcg/mL | 66.7 mcg |
Tirzepatide is a once-weekly injection that activates both the GIP and GLP-1 receptors, approved by the FDA for type 2 diabetes and chronic weight management. Large randomised trials have tested it for blood sugar, weight, sleep apnoea, heart failure and cardiovascular outcomes.
A 20 mg vial holds 20,000 mcg of Tirzepatide. Adding 2 mL gives 10 mg/mL, so one U-100 unit (0.01 mL) holds 100 mcg. To get the units for an amount, divide it by 100 mcg. The units are a volume mark on the syringe, not a measure of potency.
Vial coverage by mass: 8 full amounts of 2.5 mg, 4 full amounts of 5 mg, 2 full amounts of 7.5 mg, 2 full amounts of 10 mg, 1 full amounts of 12.5 mg, 1 full amounts of 15 mg per vial, before any handling loss.
If a different volume of water is used, every unit figure changes: recalculate with the calculator above.
Verdict: tirzepatide's evidence is strong for lowering blood sugar and body weight, with several large double-blind trials and two head-to-head comparisons with semaglutide. Evidence on hard outcomes is newer: it was not inferior to dulaglutide for heart attacks and strokes, and it reduced heart-failure events in one trial. As with semaglutide, most of the weight comes back when the drug is stopped, and almost all trials were funded by the manufacturer.
Every study dose, including animal and cell studies, is in the Tirzepatide dose table.
The most common side effects in trials were gastrointestinal: nausea, diarrhoea, vomiting, constipation and reduced appetite, mostly mild to moderate and concentrated in the dose-escalation period. In the phase 2 trial they rose with dose, from 23.1% on 1 mg to 66.0% on 15 mg (Frias 2018), and in SUMMIT side effects led 6.3% to stop the drug vs 1.4% on placebo (Packer 2025). Other known or suspected risks:
There is no single correct volume: it only changes the concentration. For a 20 mg vial, 1 mL gives 20,000 mcg/mL, 2 mL gives 10,000 mcg/mL, 3 mL gives 6,667 mcg/mL. More water makes small amounts easier to measure; less water keeps volumes small. Whatever volume is used, write it on the label.
On a U-100 syringe, 100 units = 1 mL, so one unit is 0.01 mL. How much peptide that holds depends on the concentration of the vial, which depends on how much water was added.
No. Animal doses are reported per kilogram for a different species, and scaling them to people is not reliable. That is why Upzo shows each study dose next to its study, unconverted.
Research and education only. Not medical advice. Many peptides on this site are not approved by the FDA for human use. Doses shown are the ones used in published studies and are not a recommendation. Talk to a licensed clinician before using any of them. Read the full disclaimer.
